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            "name": "Intrinsic functional connectivity of insular cortex and symptoms of sickness during acute experimental inflammation",
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            "authors": "Mats Lekander, Bianka Karshikoff, Emilia Johansson, Anne Soop, Peter Fransson, Johan N. Lundström, Anna Andreasson, Martin Ingvar, Predrag Petrovic, John Axelsson and Gustav Nilsonne",
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            "description": "Task-based fMRI has been used to study the effects of experimental inflammation on the human brain, but it remains unknown whether intrinsic connectivity in the brain at rest changes during a sickness response. Here, we investigated the effect of experimental inflammation on connectivity between areas relevant for monitoring of bodily states, motivation, and subjective symptoms of sickness. In a double-blind randomized controlled experiment, 52 healthy volunteers were injected with 0.6 ng/kg LPS (lipopolysaccharide) or placebo, and participated in a resting state fMRI experiment after approximately 2 h 45 min. Resting state fMRI data were available from 48 participants, of which 28 received LPS and 20 received placebo. Bilateral anterior and bilateral posterior insula sections were used as seed regions and connectivity with bilateral orbitofrontal and cingulate (anterior and middle) cortices was investigated. Back pain, headache and global sickness increased significantly after as compared to before LPS, while a non-significant trend was shown for increased nausea. Compared to placebo, LPS was followed by increased connectivity between left anterior insula and left midcingulate cortex. This connectivity was significantly correlated to increase in back pain after LPS and tended to be related to increased global sickness, but was not related to increased headache or nausea. LPS did not affect the connectivity from other insular seeds. In conclusion, the finding of increased functional connectivity between left anterior insula and middle cingulate cortex suggests a potential neurophysiological mechanism that can be further tested to understand the subjective feeling of malaise and discomfort during a sickness response.",
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            "owner_name": "david",
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            "name": "Similar coding of freely chosen and externally cued intentions in a fronto-parietal network",
            "DOI": "10.1016/j.neuroimage.2016.04.044",
            "authors": "David Wisniewski, Thomas Goschke and John-Dylan Haynes",
            "paper_url": "http://linkinghub.elsevier.com/retrieve/pii/S1053811916300842",
            "journal_name": "NeuroImage",
            "description": "Intentional action is essential to human behavior, yet its neural basis remains poorly understood. In order to identify neural networks specifically involved in intentional action, freely chosen and externally cued intentions have previously been contrasted. This has led to the identification of a fronto-parietal network, which is involved in freely choosing one's intentions. However, it remains unclear whether this network encodes specific intentions, or whether it merely reflects general preparatory or control processes correlated with intentional action. Here, we used MVPA on fMRI data to identify brain regions encoding non-motor intentions that were either freely chosen or externally cued. We found that a fronto-parietal network, including the lateral prefrontal cortex, premotor, and parietal cortex, contained information about both freely chosen and externally cued intentions. Importantly, MVPA cross-classification indicated that this network represents the content of our intentions similarly, regardless of whether these intentions are freely chosen or externally cued. This finding suggests that the intention network has a general role in processing and representing intentions independent of their origin.",
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            "handedness": "right",
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            "inclusion_exclusion_criteria": "Exclusion: history of neurological or psychiatric disorders, excess head movement during scanning (> 5 mm)",
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            "owner_name": "cehartwright",
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            "name": "Multiple roles for executive control in belief–desire reasoning: Distinct neural networks are recruited for self perspective inhibition and complexity of reasoning",
            "DOI": "10.1016/j.neuroimage.2012.03.012",
            "authors": "Charlotte E. Hartwright, Ian A. Apperly and Peter C. Hansen",
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            "description": "Belief–desire reasoning is a core component of ‘Theory of Mind’ (ToM), which can be used to explain and predict the behaviour of agents. Neuroimaging studies reliably identify a network of brain regions comprising a ‘standard’ network for ToM, including temporoparietal junction and medial prefrontal cortex. Whilst considerable experimental evidence suggests that executive control (EC) may support a functioning ToM, co-ordination of neural systems for ToM and EC is poorly understood. We report here use of a novel task in which psychologically relevant ToM parameters (true versus false belief; approach versus avoidance desire) were manipulated orthogonally. The valence of these parameters not only modulated brain activity in the ‘standard’ ToM network but also in EC regions. Varying the valence of both beliefs and desires recruits anterior cingulate cortex, suggesting a shared inhibitory component associated with negatively valenced mental state concepts. Varying the valence of beliefs additionally draws on ventrolateral prefrontal cortex, reflecting the need to inhibit self perspective. These data provide the first evidence that separate functional and neural systems for EC may be recruited in the service of different aspects of ToM.",
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        {
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            "owner_name": "weig@cbs.mpg.de",
            "number_of_images": 28,
            "name": "Brain, mood and cognition during treatment initiation in mild hypothyroidism",
            "DOI": "10.1530/endoabs.37.EP1049",
            "authors": "Eva Maria Quinque, Stefan Karger, Katrin Arelin, Matthias L Schroeter, Jurgen Kratzsch and Arno Villringer",
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            "journal_name": "Endocrine Abstracts",
            "description": "This collection is published here: Endocrine Abstracts (2015) 37 EP1049. It describes an additional study group from the study described here, Quinque et al. 2014: doi 10.1016/j.psyneuen.2014.01.015\r\n\r\nPatients were newly diagnosed with hypothyroidism due to Hashimoto's thyroiditis. 11 patients were recruited between June 2011 and June 2013 via local endocrinologists and among blood donors and participants of a large cohort study (LIFE). One patient had to be excluded due to a benign brain anomaly, another for a lack of hypothyroidism at study entry. Nine healthy control subjects were selected from the control sample of Quinque et al. 2014 to match the patients in age, sex and intelligence.\r\nSample description: mean age/SD patients 42+/-5, controls 38+/-8; 8 females each; IQ patients 104+/-10, controls 107+/-8. Thyroid laboratory values: patients session 1: TSH 6.1+/-1, fT3 4.8+/-1, fT4 12.6+/-2, TPO 285+/- 184; patients session 2: TSH 3.4+/-1, fT3 4.6+/-1, fT4 15.7+/-2, TPO 287+/-184; controls session 1: TSH 2.9+/- 1, fT3 4.5+/-1, fT4 14.9+/- 1, TPO 11+/-2; controls session 2: TSH 2.5+/- 1, fT3 4.4+/-0.4, fT4 14.5+/- 1, TPO 9+/-3.\r\nThe scanning protocol was identical to the one reported in Quinque et al. 2014. Analysis was identical except that data was not averaged over the two timepoints.\r\nGroups were compared at both sessions separately. In addition, paired t-tests were used to analyse changes over time in the patient group. Thirdly, the interaction between session and group was analysed in a 2x2 ANOVA design. All analyses were controlled for age and sex, VBM analyses additionally for total intracranial volume (TIV).\r\nResting-state fMRI was only available for 8 patients, because one patient panicked after the structural scan. One control subjects was equally removed from the analysis to ensure matching between the groups.\r\nThe task fMRI data was not analysed due to an unexpected performance difference even before treatment in the direction that the patients performed better.\r\nOverall conclusion: We were not able to find any group differences or changes over time that would survive classical statistical thresholds at the level of whole brain analyses or regions of interest analyses, (six ROIS as in Quinque et al. 2014 were used). As the sample was small and the disease severity and treatment effect on thyroid laboratory values likewise, we cannot conclude whether the result is due to a lack of power or whether there really are no structural and functional brain changes. Therefore, we refrain from publication, but want to make the data available for metaanalyses to avoid publication bias towards positive findings from little powered studies.\r\n",
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