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            "description": "Declining physical and cognitive functioning play critical roles in ageing, and reciprocal physio-cognitive decline is inimical to health outcomes. Brain magnetic resonance images from a community-dwelling longitudinal ageing study cohort were analysed to study neuroanatomic changes associated with physio-cognitive decline syndrome (PCDS), defined as dynapenia concomitant with impairment in any cognitive domain, but without dementia. Among 1196 eligible ≥ 50-year-olds (mean age 62) without dementia, 15.9% had PCDS. Compared to robust participants, individuals with PCDS had significantly lower grey matter volume in the bilateral amygdala and thalamus, right hippocampus, right temporo-occipital cortex, and left cerebellum VI and V regions. Diffusion-weighted tractography described disrupted hippocampus-amygdala-cerebellum connections associated with PCDS. The neuroanatomic characteristics revealed by this study provide evidence for pathophysiological processes associated with reciprocal physio-cognitive decline that may differ from those in Alzheimer’s disease, the most common form of cognitive impairment. This neurocircuit might constitute a target for future preventive interventions.",
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            "owner_name": "Bastilinho",
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            "name": "Motor imagery of hand actions: Decoding the content of motor imagery from brain activity in frontal and parietal motor areas",
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            "description": "How motor maps are organized while imagining actions is an intensely debated issue. It\r\nis particularly unclear whether motor imagery relies on action-specific representations in premotor\r\nand posterior parietal cortices. This study tackled this issue by attempting to decode the content of\r\nmotor imagery from spatial patterns of Blood Oxygen Level Dependent (BOLD) signals recorded in\r\nthe frontoparietal motor imagery network. During fMRI-scanning, 20 right-handed volunteers\r\nworked on three experimental conditions and one baseline condition. In the experimental conditions,\r\nthey had to imagine three different types of right-hand actions: an aiming movement, an\r\nextension–flexion movement, and a squeezing movement. The identity of imagined actions was\r\ndecoded from the spatial patterns of BOLD signals they evoked in premotor and posterior parietal\r\ncortices using multivoxel pattern analysis. Results showed that the content of motor imagery (i.e.,\r\nthe action type) could be decoded significantly above chance level from the spatial patterns of\r\nBOLD signals in both frontal (PMC, M1) and parietal areas (SPL, IPL, IPS). An exploratory searchlight\r\nanalysis revealed significant clusters motor- and motor-associated cortices, as well as in visual\r\ncortices. Hence, the data provide evidence that patterns of activity within premotor and posterior\r\nparietal cortex vary systematically with the specific type of hand action being imagined.",
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