Fig 2. Amyloid (PIB)-PET comparison: PCA > others | significant clusters

Contributed by relajoie on Aug. 17, 2020

Collection: Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET

Description: This map shows the significant clusters in a contrast comparing the distribution of amyloid-PET binding signal across 3 phenotypes: AD (69), PCA (21), and lvPPA (29). Model controls for age, disease severity (CDR-SoB), and global PIB SUVR. The spmT map was thresholded using the CAT12 toolbox (http://www.neuro.uni-jena.de/cat/) and 2 thresholds were selected: - liberal threshold: uncorrected P < 0.001 at the voxel level combined with FWE-corrected P < 0.05 at the cluster level - stringent threshold: FWE-corrected P < 0.05 at the voxel level - this threshold did not show any significant cluster for this specific contrast. Positive values show voxels were AD > other groups: 1 = liberal threshold only. The corresponding unthresholded spmT map is also available in this neurovault collection. The map can be better appreciated after unselecting the “smooth display” option in settings/viewer preferences.

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Warning: This map seems to be thresholded, sparse or acquired with limited field of view (99.96% of voxels are zeros). Some of the NeuroVault functions such as decoding might not work properly. Please use unthresholded maps whenever possible.
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