Fig 4. Correlation between patient age and tau-PET signal in the whole group | significant clusters

Contributed by relajoie on Aug. 17, 2020

Collection: Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET

Description: This map shows the significant clusters in a contrast looking at the negative relationship between age and FTP-PET in the whole group. Model controls for age, disease severity (CDR-SoB), and phenotype (AD (69), PCA (21), and lvPPA (29)). The spmT map was thresholded using the CAT12 toolbox (http://www.neuro.uni-jena.de/cat/) and 2 thresholds were selected: - liberal threshold: uncorrected P < 0.001 at the voxel level combined with FWE-corrected P < 0.05 at the cluster level - stringent threshold: FWE-corrected P < 0.05 at the voxel level In this images, voxels have a value of 1 if they were significant according to the liberal threshold, and 3 if they also exceeded the stringent threshold. The corresponding unthresholded T map is also available in this neurovault collection. The map can be better appreciated after unselecting the “smooth display” option in settings/viewer preferences.