Neurofunctional basis of episodic memory

Description: Episodic memory, i.e. the ability to consciously recollect information along with its context, is a significant element of human cognition. Numerous fMRI studies on subjects’ group-level reported brain regions implicated in successful encoding. It is widely unknown, however, to what extent differential responsivity of these regions explain inter-individual differences in memory performance. We analyzed a large sample of ~1500 adults who underwent a picture encoding task in the same MR scanner. Complementing a voxel-based with a network-based approach, we found that responsivity in some of the regions implicated in successful encoding as well as responsivity of six functional connectivity networks were associated with inter-individual differences in memory performance. This study offers new insights into brain regions and networks involved in inter-individual differences in episodic memory.