Triple Dissociation Replication

Description: Whole-brain analyses from the following project: ## OVERVIEW ### PROJECT NAME Limited Evidence for a Triple Dissociation in the Medial Temporal Lobe: an fMRI Recognition Memory Replication Study ### YEARS THAT PROJECT RAN 2020-2021 ### BRIEF OVERVIEW OF EXPERIMENTAL TASKS The present experiment aims to replicate two previous papers (cited below) in which authors present two analysis paths for a dataset in which participants underwent fMRI while performing a recognition memory test for old and new words. Both studies found activation in the hippocampus, with the first (Daselaar, Fleck, & Cabeza, 2006) demonstrating a distinction in hippocampus activation corresponding to true and perceived oldness of stimuli and the second (Daselaar, Fleck, Prince, & Cabeza, 2006) demonstrating that hippocampus activation reflects the subjective experience of the participant. We replicated behavioral and MRI acquisition parameters reported in these two target articles with N=53 participants and focused fMRI analyses on regions of interest reported in those articles looking at fMRI activation for differences corresponding with true and perceived oldness and those associated with subjective memory experiences of recollection, familiarity, and novelty. References: (1) Daselaar, S. M., Fleck, M. S., & Cabeza, R. (2006). Triple dissociation in the medial temporal lobes: Recollection, familiarity, and novelty. J Neurophysiol, 96(4), 1902–1911. https://doi.org/10.1152/jn.01029.2005 (2) Daselaar, S. M., Fleck, M. S., Prince, S. E., & Cabeza, R. (2006). The medial temporal lobe distinguishes old from new independently of consciousness. J Neurosci, 26(21), 5835–5839. https://doi.org/26/21/5835 [pii] 10.1523/JNEUROSCI.0258-06.2006

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