Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls

Description: Anxiety disorders are common, can result in life-long suffering, and frequently begin prior to adolescence. Research has demonstrated that adults have alterations in the pathways that connect emotion related brain regions. Since anxiety disorders often develop early in life it is important to understand if changes in these pathways are already present in childhood. Furthermore, we set out to investigate if there are sex differences in the relation between these pathways and anxiety disorders. To address these questions, we measured white matter integrity in unmedicated boys and girls with anxiety disorders. Results indicated that children with anxiety disorders indeed have significant reductions in the integrity of this pathways, and this effect was only specific to boys. Demonstrating that these effects are present early in life, are not related to medication usage, and are sex specific. Building on these findings, future research has the potential to create a better understanding of the neural alterations in anxiety disorders and begin to develop better sex specific, early life treatment targets.

Related article:

View ID Name Type
Field Value
Compact Identifier
Add DateOct. 1, 2014, 4:59 p.m.
Uploaded bydotromp
Related article DOI10.1176/appi.ajp.2018.18040425
Related article authorsDo P.M. Tromp, Lisa E. Williams, Andrew S. Fox, Jonathan A. Oler, Patrick H. Roseboom, Gregory M. Rogers, Brenda E. Benson, Andrew L. Alexander, Daniel S. Pine and Ned H. Kalin
Citation guidelines

If you use the data from this collection please include the following persistent identifier in the text of your manuscript:

This will help to track the use of this data in the literature. In addition, consider also citing the paper related to this collection.