TMD

Description: Preprocessing Pipeline FMRI data processing was carried out using FEAT (FMRI Expert Analysis Tool) Version 6.00, part of FSL (FMRIB's Software Library, www.fmrib.ox.ac.uk/fsl). The following pre-statistics processing was applied; motion correction using MCFLIRT [Jenkinson 2002]; slice-timing correction using Fourier-space time-series phase- shifting; non-brain removal using BET [Smith 2002]; spatial smoothing using a Gaussian kernel of FWHM 4.0mm; grand-mean intensity normalisation of the entire 4D dataset by a single multiplicative factor; highpass temporal filtering (Gaussian- weighted least-squares straight line fitting, with sigma=50.0s). ICA-based exploratory data analysis was carried out using MELODIC [Beckmann 2004], in order to investigate the possible presence of unexpected artefacts or activation. ICA-FIX was trained on a set of 20 scans that were hand-classified into noise and non-noise components, with the scans randomly selected from 5 bins sorting scans by the amount of average motion present to have high and low motion data in the trained set. The component classification derived from the trained data was then used in ICA-FIX to classify noise and non-noise components from all subject data and non- aggressively remove the noise components. After denoising, ICA-FIX applied a high- pass filter to each subject’s data. Registration to high resolution structural and/or standard space images was carried out using FNIRT [Jenkinson 2001, 2002]. Lastly, average time series were extract from each subject’s data based on brain nodes specified by the atlas then detrended for cubic trends and finally normalized. We used the brain parcellation proposed by Van De Ville.(Van De Ville et al. 2021). Briefly this parcellation includes a Schaefer 400 brain region cortical parcellation (Schaefer 2018, https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/brain_parcellation/Schaefer2018_LocalGlobal) combined with 16 subcortical regions and 3 cerebellar regions from the HCP release for a total of 419 nodes.