High Functioning Autism Functional Connectivity R-scored Maps

Description: 22 adolescents and young adults with ASD from the local community and from the University of Campinas. A trained and qualified clinician made the diagnosis of ASD using the DSM-5 criteria after interviewing the family and examining each patient. A second investigator confirmed the diagnosis using the “Current” Scores of the Autism Diagnostic Interview-Revised (ADI-R). The ADI-R is a clinical diagnostic instrument for assessing autism in children and adults. The ADI-R provides a diagnostic algorithm for autism as described in both the ICD-10 and DSM-IV and is one of the most important validated ASD measures available in Brazil. Child testing and parent interviews should be viewed as complimentary and necessary components of the diagnostic evaluation after the clinical evaluation and DSM-5 criteria. All patients were required to have a full-scale IQ greater than 85, as measured by the Wechsler Abbreviated Scale of Intelligence. Exclusion criteria comprised a history of major psychiatric disorders (e.g. depression, psychosis), seizure, head injury, toxic exposure and the evidence of genetic, metabolic or infectious disorders. We also excluded individuals with secondary autism related to a specific etiology such as tuberous sclerosis or Fragile X syndrome. Thirteen individuals in the ASD group were using a variety of psychoactive medications. Nine subjects were not under psychoactive drug treatment. Five subjects were taking psychostimulants, seven were taking antipsychotics and six were taking selective serotonin reuptake inhibitors (SSRIs). Six of these subjects were using more than one of the medications listed above. Participants were instructed not take any medication one day before their visit. We are including FC maps derived from 5 distinct seeds: PCC (the MNI coordinate −41 13 −29); medial frontal region (MNI 0 49 −3); left amygdala (MNI −23 −4 −20); left anterior hippocampus (MNI −24 −13 −20); left temporal pole (−41 13 −29)