Identification of Two Distinct Working Memory Related Brain Networks in Healthy Young Adults

Contributed by tobias.egli@unibas.ch

If you use data from this collection please cite:
http://doi.org/10.1523/ENEURO.0222-17.2018

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AuthorsTobias Egli, David Coynel, Klara Spalek, Matthias Fastenrath, Virginie Freytag, Angela Heck, Eva Loos, Bianca Auschra, Andreas Papassotiropoulos, Dominique J.-F. de Quervain and Annette Milnik
DescriptionWorking memory (WM) is an important cognitive domain for everyday life functioning and is often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies in humans show that distributed brain areas typically described as fronto-parietal regions are implicated in WM tasks. Based on data from a large sample of healthy young adults (N = 1369) we applied independent component analysis (ICA) to the WM-fMRI signal and identified two distinct networks that were relevant for differences in individual WM task performance. A parietally-centered network was particularly relevant for individual differences in task measures related to WM performance ('WM-dependent') and a frontally-centered network was relevant for differences in attention-dependent task performance. Importantly, frontal areas that are typically considered as key regions for WM were either involved in both WM-dependent and attention-dependent performance, or in attention-dependent performance only. The networks identified here are provided as publicly available datasets. These networks can be applied in future studies to derive a low-dimensional representation of the overall WM brain activation.
Journaleneuro
Contributors
DOI10.1523/ENEURO.0222-17.2018
Field Strength3.0
id2621
Add DateJune 26, 2017, 12:08 p.m.