Exploring variability in basal ganglia connectivity with functional MRI in healthy aging

Description: The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults. We explored the relationship between FC in the BGN and variables related to demographics, impulsive behaviour, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study (Filippini et al., 2014). Age was the only significant correlate of FC in the BGN. The observed adverse effect of ageing on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging.

Related article: http://doi.org/10.1007/s11682-018-9824-1

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Compact Identifierhttps://identifiers.org/neurovault.collection:2681
Add DateJuly 11, 2017, 11:29 a.m.
Uploaded byludogriffanti
Related article DOI10.1007/s11682-018-9824-1
Related article authorsLudovica Griffanti, Philipp Stratmann, Michal Rolinski, Nicola Filippini, Enikő Zsoldos, Abda Mahmood, Giovanna Zamboni, Gwenaëlle Douaud, Johannes C. Klein, Mika Kivimäki, Archana Singh-Manoux, Michele T. Hu, Klaus P. Ebmeier and Clare E. Mackay
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