Age-dependent association of white matter abnormality with cognition after TIA or minor stroke

Description: Previous studies have identified an association between cognitive status and MRI-detectable white matter hyperintensities (WMH), but few have focussed on older age groups. We aimed to establish whether these associations persist in TIA or non-disabling stroke patients aged >80 years in whom MRI markers of white matter damage are highly prevalent. Our results suggest that MRI markers of white matter damage in patients with TIA/minor stroke aged >80 years are unrelated to cognition, and their clinical significance should not be over-interpreted. On the contrary, the presence of WMH in patients ≤80 years should not be overlooked as they are negatively correlated with cognitive performance. Link to full paper:

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Add DateJuly 28, 2017, 12:29 p.m.
Uploaded byludogriffanti
Related article DOI10.1212/WNL.0000000000007772
Related article authorsGiovanna Zamboni, Ludovica Griffanti, Sara Mazzucco, Sarah T. Pendlebury and Peter M. Rothwell
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