Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults

Description: Relation of blood pressure (BP) and (gray matter volume) GMV in 423 healthy adults between 19-40 years without diagnosis of HTN. Includes 3 Tesla T1-weighted structural MR images and BP measurements from four cross-sectional studies that were conducted in Leipzig, Germany, between 2010-2015. Voxel-based morphometry (VBM, in SPM12 + DARTEL) was performed on each dataset separately and results were combined in image-based meta-analyses (in AES-SDM) to assess cumulative effects across datasets. Mean resting BP was assigned to one of four categories: (1) systolic BP<120 mmHg and diastolic BP<80 mmHg, (2) SBP 120-129 mmHg or DBP 80-84 mmHg, (3) SBP 130-139 mmHg or DBP 85-89 mmHg, (4) SBP≥140 mmHg or DBP≥90 mmHg. Contrasts of interest: F-contrast: the overall effect of BP category on GMV. T-contrasts (per sample and per meta-analysis): (1) linear regression with mean SBP, (2) linear regression with mean DBP, (3) category 4 vs. category 1, (4) category 3 vs. category 1, (5) category 2 vs. category 1. All analyses included total intracranial volume (TIV), gender and age as covariates.

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Add DateSept. 14, 2017, 10:19 p.m.
Uploaded byhlschaare
Related article DOI10.1212/WNL.0000000000006947
Related article authorsH. Lina Schaare, Shahrzad Kharabian Masouleh, Frauke Beyer, Deniz Kumral, Marie Uhlig, Janis D. Reinelt, Andrea M.F. Reiter, Leonie Lampe, Anahit Babayan, Miray Erbey, Josefin Roebbig, Matthias L. Schroeter, Hadas Okon-Singer, Karsten Müller, Natacha Mendes, Daniel S. Margulies, A. Veronica Witte, Michael Gaebler and Arno Villringer
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