Ventromedial prefrontal cortex connectivity during and after psychological stress in women

Description: The ventromedial prefrontal cortex (vmPFC) is purported to integrate sensory, affective, memory-related, and social information from diverse brain systems to coordinate behavioral and peripheral physiological responses according to contextual demands that are appraised as stressful. However, the functionality of the vmPFC during stressful experiences is not fully understood. Among 40 females, the present study evaluated 1) functional connectivity of the vmPFC during exposure to and recovery following an acute psychological stressor, 2) associations among individual differences in vmPFC functional connectivity, heart rate, and subjective reports of stress, and 3) whether patterns of vmPFC functional connectivity were associated with distributed brain networks. Results showed that psychological stress increased vmPFC functional connectivity with individual brain areas implicated in stressor processing (e.g., insula, amygdala, anterior cingulate cortex) and decreased connectivity with the posterior cingulate cortex and thalamus. There were no statistical differences in vmPFC connectivity to individual brain areas during recovery. Spatial similarity analyses linking patterns of vmPFC connectivity to distributed brain networks revealed stressor-evoked increased connectivity with the dorsal attention, ventral attention, and frontoparietal networks, as well as decreased connectivity with the default mode network. During recovery, vmPFC connectivity increased with the frontoparietal network. Finally, individual differences in heart rate and perceived stress were associated with vmPFC connectivity to the ventral attention, frontoparietal, and default mode networks. Psychological stress appears to alter network-level functional connectivity of the vmPFC in a manner that further relates to individual differences in stressor-evoked cardiovascular and affective reactivity.

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Add DateFeb. 12, 2018, 11:05 a.m.
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Related article DOI10.1111/psyp.13445
Related article authorsAnnie T. Ginty, Thomas E. Kraynak, Dora C. Kuan and Peter J. Gianaros
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