Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults

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AuthorsChristopher T. Smith, M. Danica San Juan, Linh C. Dang, Daniel T. Katz, Scott F. Perkins, Leah L. Burgess, Ronald L. Cowan, H. Charles Manning, Michael L. Nickels, Daniel O. Claassen, Gregory R. Samanez-Larkin and David H. Zald
DescriptionHere, we tested for a relationship between Barratt Impulsiveness Scale (BIS-11) and dopamine transporter (DAT) availability using [18F]-FE-PE2I PET in 47 adults. While our ROI-based analyses indicated a significant negative relationship between BIS-11 and BIS Motor Impulsivity and DAT availability in ventral striatum, the voxelwise results did not reach significance when corrected for multiple comparisons. Participant age and sex were controlled for in the SPM8 regression analyses and a striatal mask was applied to the analysis as FE-PE2I signal was low outside striatum, as expected given reported distribution of DAT in the human brain.
JournalTranslational Psychiatry
Field StrengthNone
Add DateJune 4, 2018, 8:32 p.m.