Acute alcohol administration dampens central extended amygdala reactivity

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AuthorsJuyoen Hur, Claire M. Kaplan, Jason F. Smith, Daniel E. Bradford, Andrew S. Fox, John J. Curtin and Alexander J. Shackman
DescriptionCitation: Hur, J., Kaplan, C. M., Smith, J. F., Bradford, D. E., Fox, A. S., Curtin, J. J., & Shackman, A. J. (in press). Acute alcohol administration dampens central extended amygdala reactivity. Scientific Reports. Alcohol use is common, imposes a staggering burden on public health, and often resists treatment, underscoring the need to develop a deeper understanding of the underlying neurobiology. The central extended amygdala (EAc)—including the bed nucleus of the stria terminalis (BST) and the central nucleus of the amygdala (Ce)—plays a key role in prominent neuroscientific models of alcohol drinking, but the relevance of these regions to acute alcohol consumption in humans remains unknown. Using a single-blind, randomized-groups design, multiband fMRI data were acquired from 49 social drinkers while they performed a well-established emotional faces paradigm after consuming alcohol or placebo. Relative to placebo, alcohol significantly dampened reactivity to emotional faces in the BST. To rigorously assess potential regional differences in activation, data were extracted from unbiased, anatomically predefined regions-of-interest. Analyses revealed similar levels of dampening in the BST and Ce. In short, alcohol transiently reduces reactivity to emotional faces and it does so similarly across the two major divisions of the human EAc. These observations reinforce the translational relevance of addiction models derived from preclinical work in rodents and provide insights into the neural systems most relevant to the consumption of alcohol and the initial development of alcohol abuse in humans.
JournalScientific Reports
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Add DateOct. 16, 2018, 6:12 p.m.