The role of the opioid system in decision making and cognitive control: A review

Description: Neural circuits involved in decision making (A) and cognitive control (B) based on meta analyses (analysis date 24 May 2018) showing forward inference maps of statistically significant (false discovery rate, p < 0.01) activations in Neurosynth (Yarkoni, Poldrack, Nichols, Van Essen, & Wager, 2011). (C) density of mu-opioid receptor expression as revealed by [11C]-carfentanil PET (mean nondisplaceable binding potential (BPND) image of 89 PET scans from healthy volunteers; courtesy of Dr. Lauri Nummenmaa)