Description: Reward processing impairments have been linked with positive and negative symptoms of schizophrenia. Here, we performed a coordinate-based meta-analysis that combined eleven BOLD-fMRI studies comparing reward anticipation signals between schizophrenia patients and healthy controls. We collected data for 488 subjects (254 schizophrenia patients and 234 controls) and 44 foci. Data were analyzed using the SDM (seed-based d mapping) algorithm. We observed a reduced difference in activation in schizophrenia patients within a frontal-striatal network. Meta-regressions revealed that this functional signature was linked to the severity of psychotic symptoms and persisted even after controlling for the dose of antipsychotic medications.
Related article: http://doi.org/10.1016/j.schres.2019.12.041
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