Description: Summary: There is a general consensus that overconsumption of sugar sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no, or low-calorie “diet” drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose sweetened beverages with, but not without a carbohydrate over 10 days, decreases insulin sensitivity in healthy human participants; an effect that correlates with reductions in midbrain, insular and cingulate responses to sweet, but not sour, salty or savory taste as assessed with fMRI. Taste perception was unaltered and consuming the carbohydrate alone had no effect. These findings indicate that consumption of sucralose in the presence of a carbohydrate rapidly impairs glucose metabolism and results in longer-term decreases in brain, but not perceptual sensitivity to sweet taste, suggesting dysregulation of gut-brain control of glucose metabolism. Current contrast T maps include: - Post-pre exposure BOLD T maps for all 3 conditions. - Post-pre exposure BOLD F map across 3 conditions. - Negative relation between post-pre BOLD maps and 0-30 min iAUC relative insulin change (post-pre) on oral glucose tolerance test for all 3 conditions.Communities: nutritional
Related article: http://doi.org/10.1016/j.cmet.2020.01.014
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