Identification of a Common Neurobiological Substrate for Mental Illness

Description: We tested for areas of common gray matter volume increase or decrease across Axis I diagnoses, as well as areas differing between diagnoses. Based on the voxel-based morphometry meta-analysis of 193 studies comprising 15 892 individuals across 6 diverse diagnostic groups (schizophrenia, bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety), we found that gray matter loss converged across diagnoses in 3 regions: the dorsal anterior cingulate, right insula, and left insula. By contrast, there were few diagnosis-specific effects, distinguishing only schizophrenia and depression from other diagnoses. In the parallel follow-up analyses of 3 healthy cohorts, we found that the common gray matter loss regions formed a tightly interconnected network during tasks and at resting and that lower gray matter in this network was associated with poor executive functioning. This dataset was automatically imported from the ANIMA <> database. Version: 1

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Add DateSept. 16, 2015, 7:35 p.m.
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Related article DOI10.1001/jamapsychiatry.2014.2206
Related article authorsMadeleine Goodkind, Simon B. Eickhoff, Desmond J. Oathes, Ying Jiang, Andrew Chang, Laura B. Jones-Hagata, Brissa N. Ortega, Yevgeniya V. Zaiko, Erika L. Roach, Mayuresh S. Korgaonkar, Stuart M. Grieve, Isaac Galatzer-Levy, Peter T. Fox and Amit Etkin
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