A short-term, high-caloric diet has prolonged effects on brain insulin action in men
Description: Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in normal-weight men. Hence, brain response to insulin can adapt to short-term changes in diet prior to weight gain and may facilitate the development of obesity and associated diseases.
Communities: nutritionalRelated article: http://doi.org/10.1038/s42255-025-01226-9
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