A whole-brain voxel-based analysis of structural abnormalities in PTSD: an ENIGMA-PGC study

Description: This collection contains the results from the meta-analysis study conducted using datasets from the ENIGMA-PGC Posttraumatic Stress Disorder (PTSD) working group. The study compared grey and white matter volume differences between PTSD patients and controls using whole-brain voxel-based morphometry (VBM) statistical maps in the meta-analysis software, Seed-based d-Mapping (https://www.sdmproject.com). We also examined differences between the following subgroups: 1) PTSD patients vs. trauma-exposed (TE) controls; 2) TE controls vs. non-TE controls (nTE); 3) Military-recruited cohorts; and 4) Civilian-recruited cohorts. We conducted several regression analyses to investigate associations between brain volumes in PTSD patients and selected clinical variables including PTSD severity, depression severity, childhood trauma, alcohol use disorder, drug use disorder, and antidepressant medication use. We performed sensitivity analyses to test for the robustness of our results by varying the VBM processing parameters and covariates, as well as for the exclusion of moderate/severe TBI subjects and non-adult subjects. Here, we present the resulting effect size (Hedges' g) maps and FWE-corrected Z-maps for each analysis.

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