Individual differences in dopamine are associated with reward discounting in clinical groups but not in healthy adults

Description: Unthresholded t-statistic maps of the linear effect of time discounting on PET dopamine D2-like receptor availability from three samples of healthy adults. Samples 1 (N=25, ages 18-24) and 2 (N=83, ages 22-81) were imaged at Vanderbilt University on a GE Discovery STE PET camera with the tracer [18F]fallypride. Sample 3 (N=34, ages 26-79) was imaged at Yale University on a Siemens HRRT PET camera with the tracer [11C] FLB 457. Linear regressions controlled for age and sex as covariates of no interest. Time discounting effects are presented for the simple proportion of smaller-sooner options (chosesnr) and computationally-derived hyperbolic discounting k-values (time_ln_k+1).

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Add DateMay 22, 2018, 10:30 p.m.
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Related article DOI10.1523/JNEUROSCI.1984-18.2018
Related article authorsJaime J. Castrellon, Kendra L. Seaman, Jennifer L. Crawford, Jacob S. Young, Christopher T. Smith, Linh C. Dang, Ming Hsu, Ronald L. Cowan, David H. Zald and Gregory R. Samanez-Larkin
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