spmT_0008_HC_smaller_AD.nii

Contributed by alexander.genauck@charite.de on Nov. 20, 2017

Collection: Reduced loss aversion in pathological gambling and alcohol dependence is associated with differential alterations in amygdala and prefrontal functioning

Description: Contrast images for gain (“neural gain sensitivity”) and loss (“neural loss sensitivity”) of all participants were subjected to two separate one-way ANOVAs with group as predictor and assumption of non-equal variance between groups. Main effect (ME) group F-Test images were computed for gain and loss and thresholded at p < 0.05, minimum cluster extent k = 10. Group main effect F-test maps were then corrected for family-wise error (FWE) at peak level using small volume correction (SVC) with our network of interest (NOI, see Supplements and online .nii file) as small volume. Note, that since the group comparison hypotheses were the same in all of the regions within the NOI it is the most stringent approach to perform one SVC for the whole NOI in the neural gain and neural loss sensitivity analysis, respectively. Then all possible one-sided post-hoc T-test images to compare HC, PG, AD were computed and peak-level FWE corrected using the NOI. This is one of the T-Tests. The map is unthresholded but the map is masked by a gray matter mask (SPM12 canonical cut off at 20% gray matter probability).

Tags: loss anticipation alcohol dependence loss sensitivity loss aversion

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