Tmaps rBPM neural gain sensitivity HCgrAD

Contributed by alexander.genauck@charite.de on Nov. 20, 2017

Collection: Reduced loss aversion in pathological gambling and alcohol dependence is associated with differential alterations in amygdala and prefrontal functioning

Description: Contrast images for gain (“neural gain sensitivity”) and loss (“neural loss sensitivity”) of all participants were subjected to two separate one-way ANOVAs with group as predictor and assumption of non-equal variance between groups. Main effect (ME) group F-Test images were computed for gain and loss and thresholded at p < 0.05, minimum cluster extent k = 10. Group main effect F-test maps were then corrected for family-wise error (FWE) at peak level using small volume correction (SVC) with our network of interest (NOI, see Supplements and online .nii file) as small volume. Note, that since the group comparison hypotheses were the same in all of the regions within the NOI it is the most stringent approach to perform one SVC for the whole NOI in the neural gain and neural loss sensitivity analysis, respectively. Then all possible one-sided post-hoc T-test images to compare HC, PG, AD were computed and peak-level FWE corrected using the NOI. Significant peak voxels from post-hoc T-tests were only considered if the FWE corrected F-Test before yielded the respective voxel also as significant. Since gray matter density (GMD) in both AD and PG has been observed different from HC53,54, and since there were significant group differences in a covariate of no interest, all found group differences in post-hoc T-test at voxels with significant SVC correctable F-Test were checked for stability by rerunning the analyses with local GMD and age using robust Biological Parametric Mapping (rBPM) with Tukey’s biweight error function using the BPMe toolbox (https://www.nitrc.org/projects/rbpm/). This is a T-contrast for HC greater than AD. Observe: was run in SPM5. Can only be viewed/evaluated in SPM8 or SPM5.

Tags: decision making loss aversion gain anticipation mixed gambles pathological gambling gain sensitivity healthy controls alcohol dependent

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