Found 4 images.
| ID | Name | Collection(s) | Description |
|---|---|---|---|
| 705877 | Sweet-spot and cold-spot locations (diary seizure outcome) | The Optimal Target and Connectivity for | Probabilistic map showing thalamic locations where centromedian deep brain stimulation (CM-DBS) yielded above-mean ("sweet-spot") and below-mean ("cold-spot") seizure reduction, as measured using monthly seizure diaries (n=19 patients with Lennox-Gastaut syndrome who participated in the "ESTEL" trial of CM-DBS). Results are provided as -log10(p-values), following a two-tailed Wilcoxon signed-rank test at each voxel with the null hypothesis equal to the mean seizure reduction across the cohort. Positive values indicate areas of above-mean seizure reduction and negative values indicate areas of below-mean seizure reduction. Values >1.301 and <-1.301 correspond to p-values <0.05. Note that results are provided for the left hemisphere only because all right-sided stimulation locations were first non-linearly flipped to the left hemisphere for this analysis. Results are saved using a voxel resolution of 0.22 mm x 0.2 mm x 0.2 mm and are provided in ICBM Montreal Neurological Institute (MNI) 2009b asymmetric template space (https://www.bic.mni.mcgill.ca/ServicesAtlases/ICBM152NLin2009). This analysis was performed using lead-DBS software version version 2.5.2 (https://www.lead-dbs.org). |
| 705878 | Sweet-spot and cold-spot locations (EEG seizure outcome) | The Optimal Target and Connectivity for | Probabilistic map showing thalamic locations where centromedian deep brain stimulation (CM-DBS) yielded above-mean ("sweet-spot") and below-mean ("cold-spot") seizure reduction, as measured using 24-hourly ambulatory EEG (n=17 patients with Lennox-Gastaut syndrome who participated in the "ESTEL" trial of CM-DBS). Results are provided as -log10(p-values), following a two-tailed Wilcoxon signed-rank test at each voxel with the null hypothesis equal to the mean seizure reduction across the cohort. Positive values indicate areas of above-mean seizure reduction and negative values indicate areas of below-mean seizure reduction. Values >1.301 and <-1.301 correspond to p-values <0.05. Note that results are provided for the left hemisphere only because all right-sided stimulation locations were first non-linearly flipped to the left hemisphere for this analysis. Results are saved using a voxel resolution of 0.22 mm x 0.2 mm x 0.2 mm and are provided in ICBM Montreal Neurological Institute (MNI) 2009b asymmetric template space (https://www.bic.mni.mcgill.ca/ServicesAtlases/ICBM152NLin2009). This analysis was performed using lead-DBS software version version 2.5.2 (https://www.lead-dbs.org). |
| 705879 | Sweet-spot and cold-spot locations (diary-EEG average seizure outcome) | The Optimal Target and Connectivity for | Probabilistic map showing thalamic locations where centromedian deep brain stimulation (CM-DBS) yielded above-mean ("sweet-spot") and below-mean ("cold-spot") seizure reduction, as measured using a diary-EEG average outcome (n=17 patients with Lennox-Gastaut syndrome who participated in the "ESTEL" trial of CM-DBS). Results are provided as -log10(p-values), following a two-tailed Wilcoxon signed-rank test at each voxel with the null hypothesis equal to the mean seizure reduction across the cohort. Positive values indicate areas of above-mean seizure reduction and negative values indicate areas of below-mean seizure reduction. Values >1.301 and <-1.301 correspond to p-values <0.05. Note that results are provided for the left hemisphere only because all right-sided stimulation locations were first non-linearly flipped to the left hemisphere for this analysis. Results are saved using a voxel resolution of 0.22 mm x 0.2 mm x 0.2 mm and are provided in ICBM Montreal Neurological Institute (MNI) 2009b asymmetric template space (https://www.bic.mni.mcgill.ca/ServicesAtlases/ICBM152NLin2009). This analysis was performed using lead-DBS software version version 2.5.2 (https://www.lead-dbs.org). |
| 779109 | Group-level comparison (LGS compared to pseudo-controls) showing areas of significant 18F-FDG-PET hypometabolism in LGS | Frontoparietal 18F-FDG-PET hypo-metabolism in Lennox-Gastaut syndrome: further evidence highlighting the key network | Results are shown as t-scores thresholded at p<0.05 (corrected for family-wise error following threshold-free cluster-enhancement) and are displayed upon the Montreal Neurological Institute (MNI)-152 6th-generation symmetric brain template. Note that this analysis was performed in the unilateral analysis space, including only structurally ‘normal’ brain hemispheres (see Methods in main manuscript for details). |