Stability of associations between neuroticism and microstructural asymmetry of the cingulum during late childhood and adolescence: Insights from a longitudinal study with up to 11 waves

Description: Neuroticism is a fundamental personality trait characterised by a tendency to experience negative and anxious emotions. Here we investigated how neuroticism is associated with maturational changes in the white matter microstructure. Longitudinal DTI data was acquired in 76 typically-developing children and adolescents aged 7-18 years over a period of six years. Participants were MR-scanned from 3 to 11 times, with an average of 8.9 times. Neuroticism was assessed up to 4 times. Tract-Based Spatial Statistics (TBSS) was used to create a mean FA skeleton, representing the centers of all with matter fiber tracts common to the group. Data were analysed using generalised additive mixed models (GAMM). Here we provide five effect size maps, i.e. unthresholded t-maps and F-maps, displaying associations of neuroticism and neuroticism-by-age with FA across the white matter skeleton in males (n=29) and females (n=47) separately, as well as of neuroticism-by-sex in the whole group.

Communities: developmental

Related article: http://doi.org/10.1002/hbm.26157