Glucocorticoid treatment for non-cerebral diseases in children and adolescents is associated with differences in uncinate fasciculus microstructure

Description: We investigated if prior glucocorticoid treatment would be associated with differences in fractional anisotropy (FA) in the uncinate fasciculi and cingulum bundle. We performed diffusion-weighted imaging in 28 children and adolescents aged 7-16 years previously treated with glucocorticoids for non-cerebral diseases (nephrotic syndrome or rheumatic disease) and 28 healthy controls. Tract-Based Spatial Statistics (TBSS) was used to create a mean FA skeleton, representing the centers of all white matter fibre tracts common to the group. Here we provide two effect-size maps, i.e. unthresholded t-maps, displaying 1) the difference in FA between patients and controls, and 2) glucocorticoid dose-response associations in patients across the white matter skeleton.

Communities: developmental

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Add DateJune 18, 2020, 1:28 p.m.
Uploaded byKathrine_Skak_Madsen
Related article DOI10.1038/s41390-021-01394-w
Related article authorsMartin Vestergaard, William F. C. Baaré, Sara K. Holm, Camilla G. Madsen, Olaf B. Paulson, Alfred P. Born, Peter Uldall, Hartwig R. Siebner and Kathrine Skak Madsen
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