Neural dynamics of semantic categorization in semantic variant of Primary Progressive Aphasia

Description: We test the hypothesis that semantic variant primary progressive aphasia (svPPA) patients, in the absence of an intact anterior temporal lobe (ATL), perform semantic tasks by over-recruiting areas implicated in perceptual processing. We acquired MEG recordings of 18 svPPA patients and 18 healthy controls during a semantic categorization task. While behavioral performance did not differ, svPPA patients showed greater activation over bilateral occipital cortices and superior temporal gyrus, and inconsistent engagement of frontal regions.

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