Sweet-spot and cold-spot locations (EEG seizure outcome)

Contributed by aaewarren on Nov. 30, 2021

Collection: The Optimal Target and Connectivity for

Description: Probabilistic map showing thalamic locations where centromedian deep brain stimulation (CM-DBS) yielded above-mean ("sweet-spot") and below-mean ("cold-spot") seizure reduction, as measured using 24-hourly ambulatory EEG (n=17 patients with Lennox-Gastaut syndrome who participated in the "ESTEL" trial of CM-DBS). Results are provided as -log10(p-values), following a two-tailed Wilcoxon signed-rank test at each voxel with the null hypothesis equal to the mean seizure reduction across the cohort. Positive values indicate areas of above-mean seizure reduction and negative values indicate areas of below-mean seizure reduction. Values >1.301 and <-1.301 correspond to p-values <0.05. Note that results are provided for the left hemisphere only because all right-sided stimulation locations were first non-linearly flipped to the left hemisphere for this analysis. Results are saved using a voxel resolution of 0.22 mm x 0.2 mm x 0.2 mm and are provided in ICBM Montreal Neurological Institute (MNI) 2009b asymmetric template space (https://www.bic.mni.mcgill.ca/ServicesAtlases/ICBM152NLin2009). This analysis was performed using lead-DBS software version version 2.5.2 (https://www.lead-dbs.org).

Tags: thalamus epilepsy lgs dbs sweet-spot lead-dbs centromedian

Task View 3D View
Warning: This map seems to be thresholded, sparse or acquired with limited field of view (99.03% of voxels are zeros). Some of the NeuroVault functions such as decoding might not work properly. Please use unthresholded maps whenever possible.
Metadata
Field Value
Citation guidelines

If you use these data please include the following persistent identifier in the text of your manuscript:

https://identifiers.org/neurovault.image:705878

This will help to track the use of this data in the literature. In addition, consider also citing the paper related to this collection.