Sweet-spot and cold-spot locations (diary-EEG average seizure outcome)

Contributed by aaewarren on Nov. 30, 2021

Collection: The Optimal Target and Connectivity for

Description: Probabilistic map showing thalamic locations where centromedian deep brain stimulation (CM-DBS) yielded above-mean ("sweet-spot") and below-mean ("cold-spot") seizure reduction, as measured using a diary-EEG average outcome (n=17 patients with Lennox-Gastaut syndrome who participated in the "ESTEL" trial of CM-DBS). Results are provided as -log10(p-values), following a two-tailed Wilcoxon signed-rank test at each voxel with the null hypothesis equal to the mean seizure reduction across the cohort. Positive values indicate areas of above-mean seizure reduction and negative values indicate areas of below-mean seizure reduction. Values >1.301 and <-1.301 correspond to p-values <0.05. Note that results are provided for the left hemisphere only because all right-sided stimulation locations were first non-linearly flipped to the left hemisphere for this analysis. Results are saved using a voxel resolution of 0.22 mm x 0.2 mm x 0.2 mm and are provided in ICBM Montreal Neurological Institute (MNI) 2009b asymmetric template space (https://www.bic.mni.mcgill.ca/ServicesAtlases/ICBM152NLin2009). This analysis was performed using lead-DBS software version version 2.5.2 (https://www.lead-dbs.org).

Tags: thalamus epilepsy lgs dbs sweet-spot lead-dbs centromedian

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